Abstract: Choroidal neovascularization, a prevalent cause of severe visual loss，has been observed in many ocular diseases.  Recent studies suggest that the Notch pathway plays a critical role in choroidal neovascularization. As a classic signaling pathway transducting in neighboring cells, Notch pathway is critically involved in several angiogenic steps, and interacted with cells and other signaling pathways. In conclusion, it is of great significance for the mechanisms and therapeutic potential to reveal its roles and mechanisms in choroidal neovascularization. (Int Rev Ophthalmol, 2014, 38: 113-118)